. 2007 Nov 13;197(3):295–311. doi: 10.1007/s00430-007-0062-1

Table 2.

Effect of doxycycline treatment on presence of Wolbachia in worms: results of immunohistology

Treatment group	Time (months)	Number of patients/nodules	Number of living female worms				Number of living male worms
			All	With Wolbachia			All^a	With Wolbachia
			All	Many	Few	None	All^a	Many	Few	None
Placebo	6	13/14	29	26	0	3	8	7	1	0
	20	16/51	70	58	7	5	25	18	2	3
	27	7/38	61	50	9	2	25	14	3	5
Doxycycline (4 weeks)	20	7/36	27	3	4	20^b	21	3	2	16^b
Doxycycline (4 weeks)	27	7/23	20	4	2	14^b	9	6	2	1
Doxycycline (6 weeks)	6	11/19	32	1	8	23^b	18	1	2	14^b
	20	13/62	42	9	033	33^b,d	20	3	2	15^b
	27	5/27	15	5	0	10^b	14	2	0	11^c,e

^aWhile the number of all living worms is given to make the numbers consistent to the other tables, in some instances it was not possible to distinguish if a male worm had many, few or no Wolbachia, due to too little worm material in the respective histological sections. Therefore, “All” is not always a summary of the three categories for males

^b,cSignificant difference between the respective doxycycline and the placebo group regarding the distribution between many, few and no Wolbachia at the respective time points (^bP < 0.0001; ^cP < 0.002, Chi-square test)

^d,eSignificant difference between the two doxycycline groups regarding the distribution between many, few and no Wolbachia at the respective time points (^dP = 0.03; ^eP = 0.003, Chi-square test)