Table 1.
Patients’ characteristics
| Tumor type | Number of patients | Somatostatin analogue pretreatment | Liver metastases | Bone metastases | CgA (µg/l) median (range) | Relevant laboratory findings median (range) |
|---|---|---|---|---|---|---|
| Carcinoids | ||||||
| -Digestive tract carcinoid | 241 | 142 | 223 | 57 | 537 (22-787,742) | Urinary 5HIAA (μmol/24 h) 222 (7-2,048) |
| -Bronchial carcinoid | 20 | 7 | 16 | 13 | 1,252 (35-900,280) | Urinary 5HIAA (µmol/24 h) 191 (15-1,440) |
| -Thymic carcinoid | 4 | 0 | 1 | 1 | 294 (147-725) | - |
| Functioning PNETs | ||||||
| -VIPoma | 3 | 0 | 3 | 9 | 153 (22-318) | VIP (pg/ml) 470 (144-710) |
| -Insulinoma | 11 | 3 | 8 | 4 | 1256 (69-21,509) | - |
| -Gastrinoma | 21 | 8 | 19 | 5 | 2,282 (111-55,715) | Gastrin (μg/l) 1.2 (0.03-22) |
| Non functioning PNETs | 124 | 25 | 107 | 24 | 385 (26-162,710) | - |
| Neuroendocrine tumour of unknown origin | 52 | 10 | 44 | 18 | 400 (23-29,110) | - |
| metastatic pheochromocytoma | 3 | 1 | 1 | 2 | 5,666 (928-6,900) | - |
| Total | 479 | 200 (42%) | 422 (88%) | 124 (26%) | ||
Digestive tract carcinoid (gastric, duodenum, short bowel, colon, and rectum carcinoids), PNETs (pancreas neuroendocrine tumors) laboratory normal values: CgA < 100 μg/l, 5HIAA < 50 μmol/24 h, VIP 25-65 pg/ml, gastrin < 0.15 μg/l.