The effects of increased FGF23 on bone and mineral homeostasis. Abbreviations: ADHR=autosomal dominant hypophosphataemic rickets; ARHR=autosomal hypophosphataemic rickets; Ca=calcium; FGF23=fibroblast growth factor 23; Pi=inorganic phosphate; PTH=parathyroid hormone; TIO=tumour-induced osteomalacia; XLH=X-linked hypophosphataemic rickets; 1,25-(OH)2D=1,25 dihydroxyvitamin D; –, suppression; +, stimulation; ↑, increased; ↓, decreased