Table 2.
Comparison of PDE7B and PDE7A
| Tissue distribution | Size
|
Km for cAMP, μM | Inhibitors at IC50, μM*
|
Function | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| mRNA, kb | Protein, aa | Predicted molecular mass, kDA | 1 | 2 | 3 | 4 | ||||
| PDE7A | 4.5 | 12.5 | 42 | 35 | Activation of T cells in immune response | |||||
| PDE7A1 | Lymphoid tissues, pancreas, placenta, brain, kidney, lung | 4.2 | 482 | 57 | 0.2 | |||||
| PDE7A2 | Skeletal muscle, heart | 3.8 | 456 | 50 | 0.1 | |||||
| PDE7B | Pancreas, brain, heart, thyroid, skeletal muscle, eye, ovary, submaxillary gland, epididymus | 5.6 | 446 | 50.1 | 0.03 | 2.1 | 22 | 9 | 44 | ??? |
*
1, IBMX; 2, papaverine; 3, dipyridamole; 4, SCH51866.