Fig 1.

(A) Example of locally advanced pancreatic cancer found at autopsy. The carcinoma measured 10 cm in greatest dimension and directly invaded the duodenum (d) and occluded the celiac artery (ce). The ultimate cause of death in this patient was bowel ischemia and peritonitis. (B) Example of a patient with limited metastatic burden at autopsy (≤ 10). Similar to that described for the carcinomas in (A), this patient also died of complications of locally advanced carcinoma (ascending cholangitis) even though at initial presentation limited metastatic disease was present. (C) Example of a patient with extensive metastatic burden at autopsy (> 1,000). The cause of death for this patient was hepatic failure secondary to massive tumor burden.