Table 3.

Relationship of Genetic Features to Patterns of Failure in Advanced Stage Pancreatic Cancer

Metastatic Burden by Gene for Primary Carcinoma	Locally Destructive				Locally Confined				P
	0		1-10		11-99		100s-1,000s
	No.	%	No.	%	No.	%	No.	%
KRAS2 (n = 59)	6/7	86	11/11	100	19/21	90	20/20	100	.283
		17/18; 94%				39/41; 95%			.672
TP53 (n = 58)	6/6	100	6/11	54	16/21	76	18/20	90	.083
		12/17; 71%			34/41; 83%			.037
DPC4 (n = 65)	2/9	22	5/11	45	17/24	71	16/22	73	.032
		7/20; 35%			33/46; 72%			.007