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. Author manuscript; available in PMC: 2009 Apr 13.
Published in final edited form as: Sci Signal. 2009 Mar 10;2(61):ra10. doi: 10.1126/scisignal.2000162

Fig. 1.

Fig. 1

Haploinsufficiency of endothelial Rac1 in mice leads to neuroprotection. EC-Rac1+/− and control mice underwent 2-hour MCAo followed by 22-hour reperfusion. (A) Representative brain sections stained with 2,3,5-triphenyltetrazolium chloride visualizing the infarct area. (B and C) Infarct (B) and edema (C) volumes of the ischemic hemisphere. (D) Neurological deficit score (n = 19 to 23 mice; *P < 0.05, Mann-Whitney test). (E) Change in CBF in the ischemic hemisphere at the end of 2-hour MCAo. (B, C, and E) Values are percent of the nonischemic hemisphere and shown as means ± SEM of 7 to 10 mice (*P < 0.05, ANOVA). NS, not significant.