Table 1.
Hemodynamic profile and arterial blood gas analysis. MABP, mean arterial blood pressure; rCBF (regional cerebral blood flow) and blood gas were measured under inhalation anesthesia in the MCAo perioperative period. Pre, before MCAo; Post, after MCAo; Paco2, partial pressure of arterial CO2; Pao2, partial pressure of arterial O2. Control, n = 7 mice; EC-Rac1+/−, n = 6 mice.
| Hemodynamic parameter | Control | EC-Rac1+/− |
|---|---|---|
| MABP (mmHg) | ||
| Pre | 91.1 ± 4.3 | 99.8 ± 3.2 |
| Post | 95.8 ± 6.0 | 102.1 ± 5.0 |
| rCBF (%) | ||
| Pre | 102.6 ± 2.5 | 102.6 ± 1.5 |
| MCAo | 8.3 ± 1.1 | 6.0 ± 1.0 |
| pH (arterial) | ||
| Pre | 7.40 ± 0.01 | 7.37 ± 0.04 |
| MCAo | 7.29 ± 0.02 | 7.25 ± 0.04 |
| Post | 7.28 ± 0.03 | 7.23 ± 0.03 |
| Paco2 (mmHg) | ||
| Pre | 29.3 ± 1.1 | 30.4 ± 3.5 |
| MCAo | 32.9 ± 3.2 | 35.5 ± 3.5 |
| Post | 48.6 ± 4.4 | 51.9 ± 4.2 |
| Pao2 (mmHg) | ||
| Pre | 120.6 ± 6.9 | 120.3 ± 16.9 |
| MCAo | 124.9 ± 9.2 | 127.5 ± 12.7 |
| Post | 127.1 ± 13.1 | 119.6 ± 7.1 |