Table 2.
Selected genes down-regulated in Rac1+/− mouse ECs. Genes are categorized by the GO annotation.
| Symbol | Gene name | Fold |
|---|---|---|
| Cell cycle | ||
| Fos | FBJ osteosarcoma oncogene | −3.02 |
| Myb | Myeloblastosis oncogene | −1.57 |
| Cdc2a | Cell division cycle 2 homolog A (Schizosaccharomyces pombe) | −2.11 |
| Ccnb2 | Cyclin B2 | −1.88 |
| Ccna2 | Cyclin A2 | −1.59 |
| Nek2 | NIMA (never in mitosis gene a)–related expressed kinase 2 | −1.85 |
| Mad2l1 | MAD2 (mitotic arrest deficient, homolog)–like 1 (yeast) | −1.60 |
| Cdca5 | Cell division cycle associated 5 | −1.54 |
| Stk6 | Aurora kinase A | −1.64 |
| Tacc3 | Transforming, acidic coiled-coil containing protein 3 | −1.93 |
| Bard1 | BRCA1 associated RING domain 1 | −1.57 |
| Gadd45g | Growth arrest and DNA-damage–inducible 45 gamma | −1.70 |
| Ect2 | ect2 oncogene | −1.65 |
| Mki67 | Ki-67 | −2.23 |
| Cytoskeleton organization and biogenesis | ||
| Kif2c | Kinesin family member 2C | −1.65 |
| Kif11 | Kinesin-related mitotic motor protein | −2.05 |
| Kif18a | Kinesin family member 18A | −1.74 |
| Kif20a | Kinesin family member 20A | −1.76 |
| Kif20b | Kinesin family member 20B | −1.73 |
| Kif22 | Kinesin family member 22 | −1.58 |
| Kif23 | Kinesin family member 23 | −1.59 |
| Tpx2 | TPX2, microtubule-associated protein homolog (Xenopus laevis) | −1.75 |
| Birc5 | Baculoviral IAP repeat–containing 5, survivin | −1.59 |
| Mapt | Microtubule-associated protein tau | −2.06 |
| Tubb6 | Tubulin, beta6 | −1.57 |
| Pfn3 | Profilin3 | −1.58 |
| Diap3 | Diaphanous homolog 3 | −1.97 |
| Chromosome organization and biogenesis | ||
| Hist1h1a | Histone 1, H1A | −1.77 |
| Hist1h1b | Histone 1, H1B | −1.99 |
| Hist1h2ab | Histone 1, H2AB | −1.57 |
| Hist2h2aa1 | Histone 2, H2AA1 | −1.52 |
| Hist1h2bb | Histone 1, H2BB | −1.74 |
| Hist2h2bb | Histone 2, H2BB | −1.73 |
| Hist1h3f | Histone 1, H3F | −1.83 |
| Hist1h3g | Histone 1, H3G | −1.94 |
| Hmgb2 | High-mobility group box 2 | −1.52 |
| Top2a | Topoisomerase (DNA) II alpha | −1.87 |