Skip to main content
. Author manuscript; available in PMC: 2010 Apr 21.
Published in final edited form as: Neuroscience. 2009 Jan 7;160(1):13–31. doi: 10.1016/j.neuroscience.2009.01.001

Table 1. Mean density values for striatal c-fos and zif268 mRNA levels.

Background corrected values for c-fos (top) and zif268 (bottom) are shown for adolescents (left) and adults (right). Italics indicate greater than age-matched saline treated animals. + indicates significantly greater than age-matched 10 mg/kg. *indicates greater than PN 65. **indicates greater than PN 28. Cocaine increased c-fos

PN 28 PN 65
Striatal Region saline 10 mg/kg 40 mg/kg saline 10 mg/kg 40 mg/kg
Rostral (+1.6)
 Dorsal Caudate 2.9 +/- 0.2 67.3 +/- 10.5* 78.8 +/- 7.9 1.6 +/- 0.6 21.3 +/- 4.2 107.6 +/- 9.5**+
 Medial Caudate 2.7 +/- 0.8 93.3 +/- 14.5* 99.8 +/- 11.0 1.6 +/- 0.5 25.0 +/- 4.3 120.3 +/- 12.1+
 Lateral Caudate 1.5 +/- 0.8 59.4 +/- 10.1* 71.2 +/- 10.5 1.4 +/- 1.0 15.3 +/- 3.6 118.8 +/- 7.0**+
 Nuc Acc Core 3.3 +/- 1.3 20.7 +/- 3.4* 25.3 +/- 4.7 2.5 +/- 1.0 7.6 +/- 1.2 33.2 +/- 7.6+
 M Nuc Acc shell 8.0 +/- 1.6 51.2 +/- 7.0* 75.3 +/- 9.7 4.7 +/- 1.5 21.8 +/- 2.6 83.0 +/- 7.8+
 V Nuc Acc shell 4.3 +/- 1.2 12.8 +/- 2.8 17.9 +/- 2.7 3.2 +/- 1.2 4.3 +/- 1.2 13.2 +/- 3.8
Medial (+0.40)
 Dorsal Caudate 3.0 +/- 0.7 61.8 +/- 8.7* 108.3 +/-9.6+ 2.9 +/- 2.5 28.6 +/- 7.0 123.7 +/- 9.5+
 Lateral Caudate 3.0 +/- 0.9 74.1 +/- 10.7* 132.7 +/- 14.5+ 3.1 +/- 0.7 27.8 +/- 7.5 136.4 +/- 10.6+
 M Vent Caudate 4.1 +/- 0.9 73.0 +/- 10.7* 119.1 +/- 13.3+ 1.7 +/- 1.8 30.1 +/- 7.5 104.4 +/- 9.4+
 Lat Vent Caudate 3.6 +/- 0.6 13.7 +/- 4.2 57.1 +/- 17.0+ 1.8 +/- 1.9 4.8 +/- 1.9 73.0 +/- 3.9+
Caudal (-0.80)
 Dorsal Caudate 4.2 +/- 1.5 86.0 +/- 11.1* 117.8 +/- 11.9+ 5.9 +/- 0.9 38.5 +/- 6.75 124.7 +/- 8.7+
 Lat Vent Caudate 1.3 +/- 0.9 4.8 +/- 1.7 58.7 +/- 19.0+ 1.9 +/- 1.5 4.4 +/- 2.5 69.5 +/- 6.1+
zif288
Rostral (+1.6)
 Dorsal Caudate 17.8 +/- 2.5* 45.4 +/- 6.5* 52.3 +/- 5.2 9.3 +/- 1.3 27.4 +/- 3.5 64.4 +/- 5.3+
 Medial Caudate 21.8 +/- 3.5* 57.1 +/- 7.6* 67.8 +/- 4.9 8.8 +/- 1.2 34.0 +/- 4.0 68.6 +/- 4.7+
 Lateral Caudate 18.2 +/- 2.8* 40.5 +/- 6.6* 47.7 +/- 5.4 9.3 +/- 1.2 25.4 +/- 3.3 61.7 +/- 4.3+
 Nuc Acc Core 11.1 +/- 1.9 25.8 +/- 6.5 26.7 +/- 3.3 5.5 +/- 1.4 11.6 +/- 2.2 38 +/- 8.2
 M Nuc Acc shell 16.2 +/- 3.5* 41.5 +/- 7.2 57.9 +/- 7.8 7.8 +/- 1.4 28.5 +/- 4.5 77.4 +/- 6.5+
 V Nuc Acc shell 11.5 +/- 2.0* 19.6 +/- 3.0 22.3 +/- 3.5 7.8 +/- 2.1 14.2 +/- 2.9 19.3 +/- 2.8
Medial (+0.40)
 Dorsal Caudate 15.5 +/- 2.5* 38.9 +/- 4.2 62.9 +/- 5.1+ 9.3 +/- 1.3 28.1 +/- 5.2 57.1 +/- 5.8+
 Lateral Caudate 16.8 +/- 2.4* 41.2 +/- 4.1 59.1 +/- 5.5+ 9.1 +/- 1.4 28.7 +/- 4.7 57.1 +/- 4.9+
 M Vent Caudate 10.3 +/- 3.4 32.2 +/- 4.0 47.8 +/- 6.3 7.3 +/- 1.9 30.1 +/- 6.3 39.4 +/- 3.9
 Lat Vent Caudate 11.9 +/- 1.6 29.2 +/- 3.7 57.8 +/- 8.4+ 6.5 +/- 1.2 21.7 +/- 3.9 53.4 +/- 5.0+
Caudal (-0.80)
 Dorsal Caudate 12.8 +/- 1.8 44.8 +/- 7.3 68.5 +/- 5.9+ 8.3 +/- 2.3 39.3 +/- 0.9 63.2 +/- 6.5+
 Lat Vent Caudate 10.4 +/- 2.5 22.9 +/- 2.7 45.3 +/- 6.6+ 8.5 +/- 2.9 20.6 +/- 3.8 50.4 +/- 2.8+