Table 3.
Predictors of Mild Cognitive Impairment (logistic regression analysis)
| Variable | Odds ratio (95% CI), p value |
||
|---|---|---|---|
| Univariate | Multivariate (with either Hoehn & Yahr stage or UPDRS motor score as measure of disease severity) |
||
| Hoehn & Yahr stage | UPDRS motor score | ||
| Age (# years) | 1.34 (1.07–1.69), 0.01 | 1.22 (0.94–1.59), 0.14 | 1.29 (1.00–1.66), 0.05 |
| Sex (male) | 0.58 (0.22–1.54), 0.28 | – | – |
| Education (# years) | 0.99 (0.86–1.14), 0.84 | – | – |
| PD duration (# years) | 0.99 (0.92–1.07), 0.86 | – | – |
| Hoehn & Yahr stage | 2.70 (1.33–5.49), 0.01 | 2.83 (1.25–6.40), 0.01 | N/A |
| UPDRS motor score | 1.05 (1.00–1.10), 0.05 | N/A | 1.05 (0.99–1.10), 0.10 |
| Levodopa dosage | 1.02 (0.92–1.14), 0.67 | – | – |
| Dopamine agonist use | 0.78 (0.34–1.80), 0.56 | – | – |
| Amantadine use | 0.71 (0.24–2.14), 0.54 | – | – |
| Anti-anxiety medication use | 3.35 (1.03–10.97), 0.05 | 3.28 (0.93–11.60), 0.07 | 3.60 (1.01–12.78), 0.05 |
| Antidepressant use | 0.69 (0.28–1.70), 0.42 | – | – |
| Antipsychotic use | 5.10 (0.45–58.47), 0.19 | – | – |
| History of DBS | 1.09 (0.31–3.83), 0.90 | – | – |
| Active depression disorder | 1.69 (0.73–3.93), 0.22 | – | – |
| IDS score | 1.15 (0.90–1.45), 0.26 | – | – |
| PPRS score | 1.31 (0.94–1.82), 0.11 | – | – |
| Apathy Scale score | 0.99 (0.93–1.07), 0.87 | – | – |
| ESS score | 0.92 (0.83–1.02), 0.10 | 0.90 (0.80–1.01), 0.08 | 0.917 (0.82–1.02), 0.13 |
| State Anxiety Inventory score | 1.01 (0.98–1.04), 0.63 | – | – |
| UPSIT score | 0.99 (0.93–1.05), 0.64 | – | – |