Table 3.
3-year disease-free survival rates for plane of surgery achieved
| Muscularis propria | Intramesorectal HR (95%CI)* | Mesorectal HR (95%CI)* | ||
|---|---|---|---|---|
| Overall | 70% | 75%, 0·82 (0·57–1·19) | 79%, 0·76 (0·53–1·09) | |
| Treatment | ||||
| Preoperative radiotherapy | 71% | 76%, 0·83 (0·48–1·44) | 82%, 0·55 (0·30–1·01) | |
| Selective postoperative chemoradiotherapy | 70% | 74%, 0·81 (0·50–1·32) | 76%, 0·94 (0·60–1·46) | |
| Sex | ||||
| Male | 68% | 73%, 0·83 (0·54–1·26) | 80%, 0·63 (0·41–0·98) | |
| Female | 75% | 79%, 0·90 (0·44–1·84) | 75%, 0·98 (0·51–1·87) | |
| Age | ||||
| ≤54 | 71% | 72%, 0·88 (0·36–2·16) | 84%, 0·43 (0·15–1·24) | |
| 55–64 | 70% | 80%, 0·65 (0·31–1·37) | 78%, 0·75 (0·38–1·50) | |
| 65–74 | 69% | 75%, 0·97 (0·54–1·74) | 76%, 1·02 (0·59–1·76) | |
| ≥75 | 69% | 74%, 0·87 (0·40–2·04) | 83%, 0·64 (0·30–1·53) | |
| Operation | ||||
| Anterior resection | 69% | 77%, 0·89 (0·51–1·57) | 79%, 0·85 (0·49–1·47) | |
| Abdominoperineal excision | 71% | 74%, 0·74 (0·44–1·25) | 83%, 0·53 (0·30–0·95) | |
| CRM | ||||
| positive | 51% | 49%, 1·05 (0·55–1·99) | 55%, 0·83 (0·43–1·62) | |
| negative | 74% | 78%, 0·87 (0·56–1·35) | 81%, 0·84 (0·55–1·28) | |
| TNM stage | ||||
| I | 88% | 93%, 0·60 (0·19–1·92) | 95%, 0·29 (0·08–1·04) | |
| II | 66% | 83%, 0·36 (0·16–0·80) | 82%, 0·51 (0·25–1·05) | |
| III | 63% | 62%, 1·12 (0·71–1·78) | 68%, 0·97 (0·61–1·54) | |
*
Compared with muscularis propria. CRM=circumferential resection margin. DFS=disease-free survival. HR=hazard ratio.