Table 1.
Diseases associated with defects in mechanotransduction
| Diseases | Primary cells/tissues affected | Select References |
|---|---|---|
| Deafness | Hair cells in inner ear | 6 |
| Arteriosclerosis | Endothelial and smooth muscle cells | 10–13, 19 |
| Muscular dystrophies and cardiomyopathies | Myocytes, endothelial cells and fibroblasts | 35, 36, 41, 85 |
| Osteoporosis | Osteoblasts | 20 |
| Axial myopia and glaucoma | Optic neurons and fibroblasts | 43–45 |
| Polycystic kidney disease | Epithelial cells | 51, 52 |
| Asthma and lung dysfunction | Endothelial cells and alveolar tissue | 15, 21–23 |
| Premature ageing (HGPS) | Multiple cell types and tissues | 55, 57 |
| Developmental disorders | Multiple cell types and tissues | 46–50, 86 |
| Cancer | Multiple cell types and tissues | 2, 58–60, 68, 71, 73, 87 |
| Potential immune system disorders | Leukocytes | 24–26 |
| Potential central nervous system disorders | Neurons | 27, 28 |