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. Author manuscript; available in PMC: 2009 Apr 14.
Published in final edited form as: Comb Chem High Throughput Screen. 2008 Dec;11(10):817–824. doi: 10.2174/138620708786734244

Fig. (5).

Fig. (5)

Results of the LOPAC library screen using the “red” GC enzyme assay. (a) Scatter plot of the results from the control DMSO plate screen. The signal-to-basal ratio was 4.1-fold with a CV of 5.5% and Z’ factor of 0.78. Scatter plots of the LOPAC library screen at (b) 3.06, (c) 15.3 and (d) 76.7 μM compound concentrations. (e) Concentration-response curves of hits with an IC50 ≤10 μM selected from the LOPAC library screen. 13 active compounds were identified, yielding a hit rate of ~1.0 %.