TABLE 4.
Cytokine Receptor SNPs Associated With Mumps-Specific Antibody Response After Mumps Immunization
| Cytokine Receptor | SNPa | Genotype | n | Median Antibody Titer, IU/mL (IQR) | Pb |
|---|---|---|---|---|---|
| IL-12RB2 | rs2201584c | CC | 84 | 877 (425–1470) | .05 |
| TC | 29 | 527 (296–876) | |||
| TT | 5 | 261 (247–697) | |||
| IL-12RB1 | rs372889c | GG | 30 | 688 (364–1187) | .03 |
| AG | 58 | 670 (361–1040) | |||
| AA | 29 | 876 (447–1592) | |||
| IL-12RB1 | rs1870063 | GG | 40 | 838 (400–1637) | .01 |
| GA | 59 | 621 (355–1040) | |||
| AA | 18 | 864 (462–1269) |
C indicates cytosine; T, thymine; G, guanine; A, adenine.
a
A total of 58 SNPs were examined; only those found to be statistically significant (P ≤.05) were included.
b
P values were based on log-transformed data using analysis of covariance, adjusting for measles antibody and lymphoproliferative response, to account for the original sampling of the individuals. Analyses are based on a subset of 118 patients.
c
SNP demonstrated an allele dose-related response.