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. Author manuscript; available in PMC: 2009 Apr 14.
Published in final edited form as: Oncogene. 2008 Mar 31;27(31):4324–4335. doi: 10.1038/onc.2008.69

Figure 8.

Figure 8

Model for the interference of α-TOS with the mitochondrial electron chain. The scheme shows the proposed effects of α-TOS with the branching of the electron transport chain in its upstream region and clarifies the point of inhibition by α-TOS as specifically interacting with complex II. It also suggests CII as the possible site of superoxide generation, although its precise location within SDH has not been identified. The possible reverse electron transport from CII to CI is also shown.