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. Author manuscript; available in PMC: 2009 Apr 14.
Published in final edited form as: Pain. 2008 Apr 9;139(1):5–14. doi: 10.1016/j.pain.2008.02.023

Fig. 3.

Fig. 3

Median effective dose (ED50) of intrathecal fentanyl using random allocation (RA). Data show effective (success) and ineffective (failure) analgesic outcomes for wild-types (Group A) and women carrying one or more 304G allele (Group G) with solid bars representing ED50 and dotted bars representing 95% confidence intervals (95% CI). ED50 was 27.4 μg (95% CI 22.5–32.2) in women 304A homozygotes (n = 77) and 12.8 μg (95% CI 5.5–20.0) in women carrying at least one 304G allele (n = 20) using per-protocol analysis (N = 97). ED50 ratio (A:G) for genotype is 2.14 (95% CI 1.30–5.17), p = 0.002.