Table 1.
Characteristic | Total, No. (%) | Hereditary, No. (%) | Nonhereditary, No. (%) |
Total no. of subjects | 1854 (100) | 1092 (100) | 762 (100) |
Laterality | |||
Unilateral | 817 (44.1) | 55 (5.0) | 762 (100.0) |
Bilateral | 1037 (55.9) | 1037 (95.0) | 0 (0.0) |
Sex | |||
Male | 956 (51.6) | 568 (52.0) | 388 (50.9) |
Female | 898 (48.4) | 524 (48.0) | 374 (49.1) |
Age at retinoblastoma diagnosis, y | |||
<1 | 769 (41.5) | 612 (56.0) | 157 (20.6) |
1 | 519 (28.0) | 306 (28.0) | 213 (28.0) |
2 | 341 (18.4) | 126 (11.5) | 215 (28.2) |
≥3 | 225 (12.1) | 48 (4.4) | 177 (23.2) |
Vital status | |||
Alive | 1380 (74.4) | 720 (65.9) | 660 (86.6) |
Deceased | 423 (22.8) | 346 (31.7) | 77 (10.1) |
Lost to follow-up | 51 (2.8) | 26 (2.4) | 25 (3.3) |
Calendar year of retinoblastoma diagnosis | |||
1914–1949 | 181 (9.8) | 106 (9.7) | 75 (9.8) |
1950–1959 | 301 (16.2) | 201 (18.4) | 100 (13.1) |
1960–1969 | 508 (27.4) | 311 (28.5) | 197 (25.9) |
1970–1979 | 448 (24.2) | 254 (23.3) | 194 (25.5) |
1980–1989 | 300 (16.2) | 171 (15.7) | 129 (16.9) |
1990–1996 | 116 (6.3) | 49 (4.5) | 67 (8.8) |
Age at last observation, y | |||
1–9 | 258 (13.9) | 184 (16.9) | 74 (9.7) |
10–19 | 291 (15.7) | 188 (17.2) | 103 (13.5) |
20–29 | 355 (19.2) | 185 (16.9) | 170 (22.3) |
30–39 | 449 (24.2) | 278 (25.5) | 171 (22.4) |
40–79 | 501 (27.0) | 257 (23.5) | 244 (32.0) |
Family history of retinoblastoma | |||
Yes | 333 (18.0) | 333 (30.5) | 0 (0.0) |
No | 1196 (64.5) | 575 (52.7) | 621 (81.5) |
Uncertain | 325 (17.5) | 184 (16.9) | 141 (18.5) |
Treatment | |||
Surgery only | 681 (36.7) | 108 (9.9) | 573 (75.2) |
Radiation only | 613 (33.1) | 534 (48.9) | 79 (10.4) |
Radiation and chemotherapy | 462 (24.9) | 408 (37.4) | 54 (7.1) |
Radiation and unknown chemotherapy | 16 (0.9) | 14 (1.3) | 2 (0.3) |
Chemotherapy only | 64 (3.5) | 21 (1.9) | 43 (5.6) |
Uncertain | 18 (1.0) | 7 (0.6) | 11 (1.4) |
Any radiotherapy | |||
Yes | 1091 (58.8) | 956 (87.5) | 135 (17.7) |
No | 752 (40.6) | 132 (12.1) | 620 (81.4) |
Uncertain | 11 (0.6) | 4 (0.4) | 7 (0.9) |
Percentages for some categories do not total 100 because of rounding.