Table 6.
Multivariable Poisson regression model of relative rate of mortality from subsequent malignant neoplasms in 1-year survivors of retinoblastoma, by hereditary status*
| Characteristic | Hereditary |
Nonhereditary |
||||
| O | RR (95% CI) | P† | O | RR (95% CI) | P† | |
| Radiation | .001 | .002 | ||||
| No or uncertain | 11 | 1.0 (referent) | 6 | 1.0 (referent) | ||
| Yes | 140 | 2.46 (1.39 to 4.84) | 6 | 7.19 (2.21 to 23.37) | ||
| Sex | .03 | .42 | ||||
| Male | 67 | 1.0 (referent) | 4 | 1.0 (referent) | ||
| Female | 84 | 1.41 (1.03 to 1.95) | 8 | 1.63 (0.51 to 6.21) | ||
| Age at retinoblastoma diagnosis, mo | .06 | .63 | ||||
| 0–12 | 95 | 1.37 (0.99 to 1.93) | 3 | 1.40 (0.31 to 4.79) | ||
| >12 | 56 | 1.0 (referent) | 9 | 1.0 (referent) | ||
| Calendar year of retinoblastoma diagnosis | .05 | .10 | ||||
| 1914–1959 | 78 | 1.44 (1.00 to 2.05) | 9 | 3.85 (0.77 to 21.02) | ||
| 1960 or later | 73 | 1.0 (referent) | 3 | 1.0 (referent) | ||
| Latency, y | <.001 | .05 | ||||
| 1–9 | 19 | 1.0 (referent) | 1 | 1.0 (referent) | ||
| 10–19 | 52 | 3.40 (2.05 to 5.90) | 3 | 3.28 (0.41 to 66.62) | ||
| 20–29 | 25 | 2.01 (0.91 to 4.22) | 2 | 0.94 (0.02 to 40.50) | ||
| 30–39 | 30 | 3.59 (1.33 to 9.56) | 0 | NA | ||
| ≥40 | 25 | 5.82 (2.09 to 15.95) | 6 | 2.79 (0.07 to 170.38) | ||
| Attained age, y | .76 | .37 | ||||
| 1–24 | 81 | 1.0 (referent) | 4 | 1.0 (referent) | ||
| ≥25 | 70 | 1.13 (0.52 to 2.56) | 8 | 4.16 (0.22 to 74.39) | ||
*
O = observed number of deaths; RR = relative rate; CI = confidence interval; NA = not applicable.
†
P value from likelihood ratio test (two-sided).