Table 3. Obesity-associated variants in PNPLA1 and PNPLA3 and the association with phenotypes using multiple regression analyses.
| SNP | BMI-SDS | Insulin sensitivity (Si*10−5/pM/min) | HOMA-IR | |
| rs9380559 | n | 323 | 271 | 224 |
| β | −0.058 | 0.0062 | −0.15 | |
| p | 0.60 | 0.73 | 0.47 | |
| AA | 6.07 (5.19–7.20) | 0.29 (0.18–0.46) | 3.40 (1.99–4.91) | |
| AG | 5.61 (4.97–5.68) | 0.33 (0.19–0.48) | 3.38 (2.46–4.52) | |
| GG | 6.03 (5.29–6.71) | 0.37 (0.25–0.49) | 3.22 (2.35–4.40) | |
| rs12212459 | n | 316 | 268 | 220 |
| β | 0.24 | 0.0098 | 0.012 | |
| p | 0.036 | 0.58 | 0.96 | |
| AA | 5.76 (4.86–6.67) | 0.32 (0.19–0.43) | 3.44 (2.48–4.61) | |
| AC | 5.76 (5.15–6.85) | 0.33 (0.19–0.49) | 3.38 (2.24–4.90) | |
| CC | 6.07 (5.30–7.56) | 0.33 (0.21–0.52) | 3.30 (1.80–4.48) | |
| rs1467912 | n | 329 | 276 | 229 |
| β | 0.26 | 0.0048 | −0.068 | |
| p | 0.022 | 0.80 | 0.76 | |
| CC | 5.82 (4.95–6.68) | 0.32 (0.19–0.45) | 3.36 (2.45–4.61) | |
| CT | 5.66 (5.08–6.69) | 0.34 (0.20–0.51) | 3.35 (2.10–4.74) | |
| TT | 6.22 (5.53–7.61) | 0.32 (0.21–0.46) | 3.43 (2.27–4.63) | |
| rs4713951 | n | 326 | 275 | 228 |
| β | 0.22 | −0.014 | −0.080 | |
| p | 0.052 | 0.45 | 0.72 | |
| CC | 5.66 (4.98–6.68) | 0.33 (0.20–0.47) | 3.30 (2.45–4.19) | |
| CT | 5.81 (5.02–6.90) | 0.31 (0.18–0.49) | 3.64 (2.34–4.83) | |
| TT | 6.11 (5.37–7.37) | 0.33 (0.22–0.42) | 3.19 (1.92–4.53) | |
| rs10947600 | n | 327 | 275 | 228 |
| β | 0.024 | 0.015 | −0.28 | |
| p | 0.83 | 0.41 | 0.20 | |
| GG | 5.89 (4.97–6.88) | 0.33 (0.18–0.48) | 3.56 (2.49–5.03) | |
| GA | 5.83 (5.12–6.93) | 0.33 (0.21–0.48) | 3.25 (2.31–4.55) | |
| AA | 5.83 (5.02–7.01) | 0.28 (0.19–0.45) | 3.24 (1.89–4.78) | |
| rs12199580 | n | 323 | 271 | 224 |
| β | 0.078 | 0.0067 | −0.38 | |
| p | 0.48 | 0.72 | 0.088 | |
| CC | 5.82 (4.92–6.68) | 0.34 (0.19–0.49) | 3.54 (2.46–5.21) | |
| CA | 5.87 (5.14–6.97) | 0.33 (0.21–0.47) | 3.33 (2.45–4.54) | |
| AA | 5.83 (5.14–7.05) | 0.28 (0.19–0.45) | 3.07 (1.83–4.61) | |
| rs139051 | n | 326 | 274 | 227 |
| β | −0.060 | −0.0223 | 0.14 | |
| p | 0.59 | 0.23 | 0.46 | |
| GG | 5.90 (4.98–7.15) | 0.33 (0.22–0.50) | 3.43 (2.37–4.58) | |
| GA | 5.75 (5.00–6.57) | 0.33 (0.18–0.47) | 3.35 (2.30–4.80) | |
| AA | 5.95 (5.14–6.89) | 0.30 (0.21–0.42) | 3.61 (2.34–4.75) | |
| rs12483959 | n | 324 | 274 | 228 |
| β | 0.029 | −0.053 | −0.30 | |
| p | 0.83 | 0.016 | 0.25 | |
| GG | 5.83 (5.00–7.09) | 0.33 (0.21–0.49) | 3.32 (2.36–4.63) | |
| GA | 5.81 (5.05–6.54) | 0.33 (0.16–0.42) | 3.56 (2.39–5.03) | |
| AA | 6.14 (5.28–7.32) | 0.34 (0.28–0.65) | 2.50 (2.14–4.00) | |
| rs2072907 | n | 327 | 275 | 229 |
| β | 0.034 | −0.049 | −0.21 | |
| p | 0.79 | 0.024 | 0.40 | |
| GG | 5.81 (4.99–7.04) | 0.33 (0.22–0.49) | 3.29 (2.35–4.63) | |
| GC | 5.88 (5.02–6.65) | 0.27 (0.16–0.42) | 3.56 (2.39–4.72) | |
| CC | 6.24 (5.47–7.16) | 0.33 (0.25–0.64) | 2.67 (2.28–4.48) |
p-values are calculated using multiple regression including gender and age as covariates. SNP – Single nucleotide polymorphism. n – number of observations, β– Regression coefficient, p - p-value for t-statistic. f – fasting samples, BMI-SDS – Body Mass Index - Standard Deviation Score, HOMA-IR – homeostasis model of assessment - Insulin Resistance.