Table 2.

SNPs With Significant p Values for Association With Clinical Otosclerosis in the Belgian-Dutch Population

Gene	SNP	Region	Nucleotide change*	Amino acid change†	Interaction‡	Additive§	Dom/Rec¶
BMP2	rs3178250	3′UTR	g.6700201T>C		0.303	0.215	0.007
BMP4	rs17563	Exon 4	g.35417272A>G	p.Ala152Val	0.404	0.028
CD46	rs2796267	5′ gene flanking region	g.1442685G>A		0.022	F:0.392
						M:0.024
	rs2796270	Intronic	g.1455391G>A		0.003	F:0.062
						M:0.021
FGF2	rs167428	Intronic	g.48321586T>C		0.560	0.052	0.027
	rs17407577	Intronic	g.48327488T>C		0.275	0.044
	rs1960669	Intronic	g.48330715C>A		0.982	0.006
OTOR	rs6044284	3′ gene flanking region	g.16674689G>A		0.349	0.016
PTH	rs6254	Intronic	g.12301504C>T		0.003	F:0.008
						M:0.087
	rs751610	Intronic	g.12303620C>T		0.009	F:0.116
						M:0.039
RARA	rs4890109	Intronic	g.2232400G>T		0.867	0.012
SLAMF1	rs2295612	Exon 1	g.11107058G>T	p.Phe11Leu	0.637	0.019
LCT	rs4988235**	5′ gene flanking region	g.25316568G>A		0.472	0.242

* The following nucleotide reference sequences were used:for BMP2, NT_011387.8; for BMP4, NT_026437.11; for CD46, NT_021877.18; for FGF2, NT_016354.18; for OTOR, NT_011387.8; for PTH, NT_009237.17; for RARA, NT_010755.15; for SLAMF1, NT_004487.18; for LCT, NT_022135.15.

^† The following protein reference sequences were used:for BMP4, NP_001193.1; for SLAMF1, NP_003028.1.

^‡ Interaction for sex assuming an additive model.

^§ p value assuming an additive model; F, females; M, males.

^¶ p value assuming a dominant/recessive model.

** Included to assess population stratification.