Table 1. Association between rs17782313 and BMI in populations with genome-wide association data andin replication populations.
| MAF (%) | T/T | C/T | C/C | |||
|---|---|---|---|---|---|---|
|
|
||||||
| n | Mean BMIa (95% CI) |
Mean BMIa (95% CI) |
Mean BMIa (95% CI) |
P b | ||
| GWA population-based studies | ||||||
| EPIC-Obesity study | 2,416 | 24 | 26.0 (25.9–26.2) |
26.3 (26.1–26.5) |
26.5 (26.0–27.1) |
0.029 |
| CoLaus | 5,631 | 24 | 25.4 (25.3–25.6) |
25.6 (25.4–25.8) |
25.8 (25.3–26.3) |
0.016 |
| British 1958 Birth Cohort | 1,479 | 23 | 26.9 (26.6–27.2) |
27.2 (26.8–27.6) |
28.0 (26.8–29.2) |
0.017 |
| WTCCC/UK Blood Services 1 | 1,456 | 24 | 25.7 (25.5–26.0) |
26.1 (25.7–26.4) |
26.3 (25.4–27.1) |
0.08 |
| Replication population-based studies | ||||||
| EPIC-Norfolk | 15,834 | 23 | 26.0 (25.9–26.0) |
26.1 (26.0–26.2) |
26.3 (26.1–26.5) |
0.0006 |
| MRC-Ely | 1,696 | 25 | 26.8 (26.6–27.1) |
26.9 (26.7–27.3) |
26.6 (25.8–27.4) |
0.95 |
| Northern Finnish Birth Cohort of 1966 | 4,830 | 18 | 24.3 (24.2–24.5) |
24.5 (24.3–24.7) |
24.9 (24.2–25.5) |
0.034 |
| Oxford Biobank | 1,165 | 24 | 25.6 (25.3–25.9) |
26.0 (25.6–26.4) |
26.7 (25.7–27.7) |
0.018 |
| UK Blood Services 2 | 1,562 | 24 | 25.9 (25.6–26.1) |
25.9 (25.6–26.2) |
26.4 (25.6–27.3) |
0.34 |
| ALSPAC Mothers | 6,264 | 24 | 22.7 (22.6–22.8) |
22.7 (22.6–22.9) |
22.9 (22.6–23.3) |
0.19 |
| Hertfordshire study | 2,842 | 24 | 26.9 (26.7–27.1) |
27.3 (27.1–27.5) |
27.2 (26.6–27.8) |
0.03 |
| SardiNIA | 1,412 | 12 | 24.5 (24.2–24.9) |
24.7 (24.1–25.3) |
23.4 (21.7–25.2) |
0.11 |
| KORA | 1,642 | 26 | 26.9 (26.6–27.1) |
27.2 (26.9–27.5) |
27.6 (26.9–28.3) |
0.02 |
| NHS | 2,265 | 24 | 24.6 (24.4–24.8) |
25.1 (24.8–25.4) |
24.1 (23.5–24.8) |
0.24 |
| PLCO | 2,238 | 24 | 27.2 (27.0–27.4) |
27.2 (27.0–27.5) |
28.0 (27.3–28.7) |
0.11 |
| Dundee controls 1 | 1,913 | 22 | 26.2 (26.0–26.5) |
26.4 (26.1–26.7) |
27.0 (26.1–27.9) |
0.11 |
| Dundee controls 2 | 1,501 | 22 | 26.5 (26.2–26.8) |
26.8 (26.4–27.2) |
26.5 (25.6–27.5) |
0.35 |
| EFSOCH | 1,639 | 23 | 24.6 (24.3–24.8) |
25.3 (24.9–25.6) |
25.9 (25.0–26.8) |
0.00004 |
| DGI controls | 1,503 | 22 | 26.3 (26.1–26.6) |
26.6 (26.3–26.9) |
26.3 (25.5–27.2) |
0.35 |
| FUSION controls | 1,291 | 19 | 26.8 (26.5–27.0) |
26.8 (26.4–27.2) |
26.4 (25.5–27.3) |
0.58 |
| Meta-analyses of population-based studies (I2 = 2.5%, P for heterogeneity = 0.43) | 1.6 × 10−15 | |||||
| GWA case series | ||||||
| WTCCC/T2D cases | 1,923 | 26 | 30.6 (30.3–31.0) |
30.7 (30.3–31.1) |
30.8 (29.9–31.8) |
0.69 |
| WTCCC/CAD cases | 1,974 | 25 | 27.3 (27.1–27.6) |
27.2 (26.9–27.5) |
27.7 (27.0–28.5) |
0.76 |
| WTCCC/HT cases | 1,947 | 23 | 27.0 (26.8–27.2) |
27.6 (27.3–27.9) |
27.5 (26.8–28.3) |
0.004 |
| Replication case series | ||||||
| Dundee cases 1 | 1,909 | 24 | 30.9 (30.6–31.3) |
30.9 (30.5–31.3) |
31.7 (30.6–32.8) |
0.68 |
| Dundee cases 2 | 1,067 | 24 | 31.0 (30.6–31.5) |
31.5 (30.9–32.1) |
31.3 (29.9–32.7) |
0.29 |
| YT2D–OXGN cases | 617 | 25 | 31.4 (30.7–32.1) |
31.7 (30.9–32.5) |
31.4 (29.3–33.6) |
0.71 |
| DGI cases | 1,543 | 23 | 28.3 (28.0–28.6) |
28.0 (27.7–28.4) |
28.0 (27.1–29.0) |
0.26 |
| FUSION cases | 1,094 | 18 | 29.8 (29.4–30.1) |
30.1 (29.6–30.6) |
29.0 (27.4–30.7) |
0.86 |
| Meta-analyses of case series (I2 = 20%, P for heterogeneity = 0.27) | 0.11 | |||||
| Meta-analyses of all studies (I2 = 15%, P for heterogeneity = 0.24) | 2.8 × 10−15 | |||||
a
BMI is presented as geometric means and log-inverse 95% confidence intervals.
b
P values represent significance of the additive model (per-allele effect) with standardized log10-transformed BMI, adjusted for age.