Table 5. Pathological lesions and antigen distribution in tissues of nonhuman primates infected with H5N1 viruses.
| Challenge virus | Animal | Vaccination with AH/AAca | Tra | Bro(R) | Bro(L) | Right lungs | Left lungs | Tonsil | TBLN | ||||
| Upper | Middle | Lower | Upper | Middle | Lower | ||||||||
| AH/05 | V1 | + | −/−b | −/− | −/− | +/− | −/− | ++/− | +/− | −/− | +/− | −/− | −/− |
| V2 | + | −/− | −/− | −/− | +/− | +/− | +/− | +/− | −/− | ++/− | −/− | −/− | |
| C1 | − | −/− | −/− | −/− | ++/+ | +/+ | ++/++ | +/− | +/− | ++/++ | −/− | −/− | |
| C2 | − | −/− | −/− | −/− | ++/+ | −/− | +/− | +/− | −/− | ++/− | −/− | −/− | |
| BHG/05 | V3 | + | −/− | −/− | −/− | +/− | −/− | −/− | +/− | −/− | +/− | −/− | −/− |
| V4 | + | −/− | −/− | −/− | +/− | +/− | +/− | −/− | +/− | −/− | −/− | −/− | |
| C3 | − | −/− | −/− | −/− | +/+ | +++/++ | ++/++ | +/− | +/− | +/+ | −/− | −/− | |
| C4 | − | −/− | −/− | −/− | ++/++ | ++/++ | ++/++ | +/− | +/+ | ++/++ | +/+ | −/− | |
Animals were vaccinated twice (4-week interval) with AH/AAca and challenged with AH/05 or BHG/05 virus. Tissues for pathological examination were collected 3 days after viral challenge. Tra, trachea; Bro, Bronchus; TBLN, tracheobronchial lymph node.
b
Pathological lesions/viral antigens. −, no pathological change/antigen. +, limited pathological change/antigen. ++, moderate pathological change/antigen. +++, severe pathological change/abundant antigen.