Table 1. Average full-field ERG values at various timepoints.
Nanoparticle | Naked DNA | Changeb | Pb | ||||
Averagea±SEM | #c | Averagea±SEM | #c | ||||
PI-30 | |||||||
Scotopic-A | CBA-NMP | 134.8±13.3 | 19 | 92.9±9.4 | 6 | 41.9 µV, 45.1% | 0.018 |
IRBP-NMP | 146.7±13.7 | 15 | 96.0±11.0 | 9 | 50.7 µV, 52.8% | 0.018 | |
Photopic-B | CBA-NMP | 148.1±11.3 | 19 | 98.7±15.2 | 6 | 49.4 µV, 50.1% | 0.035 |
IRBP-NMP | 134.4±13.7 | 15 | 92.4±9.7 | 9 | 42.0 µV, 45.4% | 0.040 | |
PI-60 | |||||||
Scotopic-A | CBA-NMP | 107.7±7.8 | 5 | 81.8±17.2 | 4 | 25.9 µV, 31.7% | 0.061 |
IRBP-NMP | 148.4±8.9 | 10 | 70.5±18.8 | 4 | 77.9 µV, 110.4% | 0.011 | |
Photopic-B | CBA-NMP | 117.3±19.7 | 5 | 131.0±11.3 | 4 | −13.7 µV, −11.5% | 0.594 |
IRBP-NMP | 194.8±16.0 | 10 | 64.5±20.4 | 4 | 130.3 µV, 202.0% | 0.0007 | |
PI-120 | |||||||
Scotopic-A | CBA-NMP | 123.9±12.9 | 5 | 77.1±17.3 | 6 | 46.8 µV, 60.7% | 0.086 |
IRBP-NMP | 129.4±9.6 | 5 | 67.6±16.2 | 5 | 61.8 µV, 91.4% | 0.011 | |
Photopic-B | CBA-NMP | 120.8±14.83 | 5 | 108.0±13.48 | 6 | 12.8 µV, 11.8% | 0.54 |
IRBP-NMP | 185.6±20.6 | 5 | 87.9±20.5 | 5 | 97.7 µV, 111.1% | 0.009 |
Values are mean µV±S.E.M.
Comparison between nanoparticle and naked DNA using 2-tailed un-paired Student's t-test as described in methods.
Number of animals tested.