FIG. 1.

The glutathione redox system and yeast methanol metabolism. Aox, alcohol oxidase; Das, dihydroxyacetone synthase; Cta, catalase; Fld, HCHO dehydrogenase; Fgh, S-formylglutathione hydrolase; Fdh, formate dehydrogenase; Pmp20, peroxisomal glutathione peroxidase; Gpx, glutathione peroxidase; GS-CH₂OH, S-hydroxymethylglutathione; GS-CHO, S-formylglutathione; Xu5P, xylulose 5-phosphate; DHA, dihydroxyacetone; GAP, glyceraldehyde 3-phosphate; ROOH (where R is an aliphatic or aromatic organic group or simply hydrogen), alkyl hydroperoxide. Dashed arrow, hydroxyl radicals from H₂O₂ attack the peroxisomal membrane, resulting in the generation of ROOH (14). Yap1-targeted enzymes are boxed.