TABLE 5.
C. albicans tissue burdens among mice with HDCa
| Organ and strain | Mean log10 CFU/g of tissueb ± SD at:
|
||
|---|---|---|---|
| 6 h | 24 h | 72 h | |
| Kidney | |||
| SC5314 | 4.22 ± 0.12 | 5.17 ± 0.27 | 5.59 ± 0.09 |
| rfx2 mutant | 4.74 ± 0.10 (0.03) | 5.11 ± 0.12 (NS) | 4.48 ± 0.14 (<0.0001) |
| Liver | |||
| SC5314 | 3.23 ± 0.05 | 3.03 ± 0.13 | 2.38 ± 0.31 |
| rfx2 mutant | 4.00 ± 0.04 (<0.0001) | 3.08 ± 0.14 (NS) | 2.56 ± 0.26 (NS) |
| Spleen | |||
| SC5314 | 3.94 ± 0.15 | 3.41 ± 0.66 | 3.06 ± 0.48 |
| rfx2 mutant | 4.11 ± 0.31 (NS) | 3.79 ± 0.32 (NS [P = 0.1]) | 2.92 ± 0.37 (NS) |
a
Mice were infected via lateral tail vein injection with 5 × 105 CFU/mouse. They were sacrificed at 6, 24, and 72 h. The kidneys, spleens, and livers were removed for CFU enumeration.
b
Significance (P values or NS [not significant]) for the wild type versus mutants is indicated in parentheses.