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Comparison of sequences of DHFR from C. glabrata (CgDHFR), P. jirovecii (PjDHFR), P. carinii (PcDHFR), and human (hDHFR) (A) and of the structures of CgDHFR (black) and PcDHFR (gray) bound to antifolates and NADPH (ligands are shown in stick form) (B).
