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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Immunol Rev. 2009 Mar;228(1):74–92. doi: 10.1111/j.1600-065X.2008.00740.x

Fig. 8. Peptide substrate recognition.

Fig. 8

A detailed view of the active site of insulin receptor kinase (Irk) shows a peptide substrate, containing the sequence YMNM (orange) forming an anti-parallel β sheet with the activation loop of the kinase (labeled and indicated by dashed box). The kinase is colored green and depicted with ribbons. The tyrosine (Y) and two methionines (M) of the peptide substrate are labeled. The Irk active site also contains the non-hydrolyzable ATP analog adenylyl diphosphate (AMP-PNP), depicted with sticks and colored red. The C-helix of the N-terminal kinase lobe is labeled.