Table 3.

Association of the IL-18 Serum Level Altering SNP rs5744256 With Short Physical Performance Battery Scores and Walking Times in Participants Aged 65–80 Years in the InCHIANTI and Iowa-EPESE Studies

		TT		Genotype TC		CC		Total
Study	Tested Physical Performance	N	Mean (95% CI)	N	Mean (95% CI)	N	Mean (95% CI)	N	Linear Regression Coefficient (95% CI)*	p Value
InCHIANTI	Summary Physical Performance Battery	445	10.48 (10.24–10.72)	201	10.87 (10.59–11.15)	28	10.96 (10.37–11.56)	674	0.283 (−0.02 to 0.58)	.065
	7-m walk times	436	6.42 (6.17–6.79)	198	5.93 (5.721–6.13)	28	6.01 (5.46–6.57)	662	−0.038 (−0.07 to −0.01)	.016
Iowa-EPESE	Summary Physical Performance Battery	557	8.45 (8.24–8.67)	376	8.45 (8.18–8.73)	64	9.22 (8.63–9.81)	997	0.222 (−0.04 to 0.48)	.092
	8-ft walk times	556	3.99 (3.84–4.14)	375	3.94 (3.75–4.12)	64	3.49 (3.15–3.83)	995	−0.040 (−0.08 to −0.005)	.026

^*Notes: All models were adjusted for age and sex, and Iowa models (which included only participants reporting being white) were adjusted for origin of parental families (known vs unknown): dependent variable logged.

IL-18 = Interleukin-18; SNP = single nucleotide polymorphism; EPESE = Established Populations for Epidemiological Study of the Elderly; CI = confidence interval.