Table 4. Hazard Ratios (HRs) and 95% Confidence Intervals for Hip Fracture (HF) Stratified by Age Groups From Cox Proportional Hazards Regression Models^a.

	Age<80 y (n = 659)					Age ≥80 y (n = 161)
Brain MR Imaging Pattern	Crude	Plus Age and Sex	Plus Osteoporosis	Plus Other Risk Factorsb	Plus Variables in the Causal Pathwayc	Crude	Plus Age and Sex	Plus Osteoporosis	Plus Other Risk Factorsb	Plus Variables in the Causal Pathwayc
Diffuse WMLs	3.1 (1.2-7.9) P=.002	2.7 (1.0-6.9) P=.01	2.7 (1.0-6.9) P=.03	2.7 (1.1-7.1) P=.04	2.4 (0.9-7.1) P=.07	1.1 (0.3-3.7)	0.9 (0.2-3.0)	0.6 (0.1-2.2)	0.5 (0.1-2.9)	0.5 (0.1-3.3)
Focal lesions	1.9 (0.5-6.7)	2.1 (0.6-7.8)	2.3 (0.6-8.6)	2.0 (0.6-7.6)	2.1 (0.5-8.2)	0.34 (0.04-3.30)	0.20 (0.02-2.30)	0.20 (0.02-1.70)	0.15 (0.01-1.60)	0.2 (0.1-2.4)
No lesions	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]

Abbreviations: MR, magnetic resonance; WMLs, white matter lesions.

^aData are given as HR (95% confidence interval) unless otherwise indicated. Variables were considered for these models if P<.10 in bivariate analyses.

^bEducation, smoking, and number of medications.

^cPrevious HF, previous falls, physical activity, systolic blood pressure, Mini-Mental State Examination score, short physical performance battery score, and taking high blood pressure medication.