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. Author manuscript; available in PMC: 2010 Mar 26.
Published in final edited form as: J Med Chem. 2009 Mar 26;52(6):1612–1618. doi: 10.1021/jm800789h

Figure 1.

Figure 1

Inhibition by peptides 29 (Panel A) and 30 (Panel B) of binding of Shc to hepatocyte growth factor receptor (c-Met) tyrosine kinase in intact B5/589 cells as described in Experimental Section. Cells were incubated for 1 h in presence (10 μM) or absence (0 μM) of the indicated peptides, then untreated (control) or briefly stimulated with HGF (+HGF). Cells were lysed and the amount of Shc bound to c-Met determined (upper panels) as well as the amount c-Met recovered (lower panels).