. Author manuscript; available in PMC: 2010 Mar 26.

Published in final edited form as: J Med Chem. 2009 Mar 26;52(6):1612–1618. doi: 10.1021/jm800789h

Table 2.

Shc SH2 domain-binding affinities for FITC-X-pY-Q-G-L-S-amide.

No	K_d ± s.d (μM)^a	No.	K_d ± s.d (μM)^a
16	8.6 ± 0.9	23	5.0 ± 0.9
17	9.0 ± 3.2	24	0.77 ± 0.04
18	5.3 ± 0.6	25	14.2 ± 2.1
19	9.5 ± 1.1	26	25.4 ± 1.6
20	18.0 ± 0.8	27	0.5 ± 0.3
21	23.9 ± 2.0	28	12.3 ± 2.3
22	poor

Determined by a direct binding fluorescence anisotropy assay as described in the experimental procedures.