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. Author manuscript; available in PMC: 2010 Jan 15.
Published in final edited form as: Bioorg Med Chem. 2008 Dec 3;17(2):634–640. doi: 10.1016/j.bmc.2008.11.064

Table 1.

In Vitro results of HTS hits with the naphthoquinone scaffold.

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Compound Luciferase Assaya Her2 ELISA IC50c Anti-Proliferation IC50c
MCF-7 SKBr3
HTS1 0.25b 3.3 ± 1 0.21 ± 0.02 0.82 ± 0.02
HTS2 0.38 1.2 ± 0.2 19 ± 4 2.9 ± 0.5
HTS3 0.02 1.2 ± 0.3 0.83 ± 0.13 0.87 ± 0.23
a

All values are reported in μM

b

Values represent the IC50 of a representative luciferase refolding assay.

c

Values are mean ± SEM of three separate experiments performed in triplicate.