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. Author manuscript; available in PMC: 2010 Jan 15.

Published in final edited form as: Bioorg Med Chem. 2008 Dec 3;17(2):634–640. doi: 10.1016/j.bmc.2008.11.064

Table 3.

In vitro activity of benzamide naphthoquinones.

Compound	Her2 ELISA IC₅₀^a	Anti-Proliferation IC₅₀^a
Compound	Her2 ELISA IC₅₀^a	MCF-7	SKBr3
HTS1	3.3 ± 1	0.21 ± 0.02	0.82 ± 0.02
4a	3.8 ± 0.6	2.1 ± 0.4	6.8 ± 0.1
4b	3.0 ± 1.4	2.2 ± 0.1	1.9 ± 0.7
4c	2.7 ± 0.7	1.4 ± 0.1	2.6 ± 0.02
4d	2.8 ± 0.9	1.4 ± 0.02	4.0 ± 1.8
4e	1.8 ± 0.4	1.8 ± 0.1	4.0 ± 0.4
4f	6.3 ± 1.5	4.8 ± 2.0	12.7 ± 0.6
4g	1.8 ± 0.5	2.6 ± 0.1	8.5 ± 0.6
4h	>100	6.0 ± 0.1	>100
4i	>100	23 ± 1.9	>100
6	30.1 ± 1.1	1.8 ± 0.3	2.1 ± 0.1

^a

Values are mean ± SEM of three separate experiments performed in triplicate and reported in μM.