Table 4.
In vitro activity of p-OMe/Benzamide derivatives.
| Compound | Her2 ELISA IC50a | Anti-Proliferation IC50 | |
|---|---|---|---|
| MCF-7 | SKBr3 | ||
| HTS1 | 3.3 ± 1 | 0.21 ± .02 | 0.82 ± .02 |
| 11 | >100 | >100 | >100 |
| 12 | 1.7 ± 0.04 | 3.0 ± 0.4 | 1.7 ± 0.5 |
| 13a | 2.0 ± 0.06 | 2.2 ± 0.1 | 5.5 ± 0.9 |
| 13b | 12.9 ± 0.4 | 3.4 ± 1.5 | 9.5 ± 2.3 |
| 13c | 3.0 ± 0.2 | 3.3 ± 1.2 | 3.0 ± 1.7 |
| 13d | 5.8 ± 0.8 | 2.1 ± 0.1 | 7.9 ± 0.8 |
| 13e | 44.2 ± 4.0 | 1.8 ± 0.1 | 6.4 ± 0.2 |
| 13f | 2.4 ± 0.08 | 1.5 ± 0.3 | 6.4 ± 0.1 |
| 13g | 9.9 ± 0.9 | 2.2 ± 0.3 | 5.8 ± 1.1 |
| 13h | >100 | 6.8 ± 0.6 | >100 |
| 13i | 2.5 ± 1.2 | 1.9 ± 0.6 | 4.8 ± 1.3 |
a
Values are mean ± SEM of three separate experiments performed in triplicate and reported in μM.