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Firefly luciferase renaturation.
| Compound | IC50a |
|---|---|
| HTS1 | 0.25b |
| 3b | 1.6 ± 0.5 |
| 3g | 0.2 ± 0.03 |
| 4b | 39 ± 16 |
| 4g | 1.4 ± 0.3 |
| 5 | 5.0 ± 1.5 |
| 11 | 86 ± 22 |
| 12 | 1.6 ± 0.4 |
| 13e | 2.5 ± 1.6 |
| 13f | 24.0 ± 15 |
| 13i | 1.4 ± 0.3 |
Values are mean ± SEM of three separate experiments performed in triplicate and reported in μM.
Value represents the IC50 value from a luciferase refolding assay
