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. Author manuscript; available in PMC: 2009 Apr 15.
Published in final edited form as: Nat Rev Neurosci. 2008 Sep;9(9):678–685. doi: 10.1038/nrn2463

Figure 2. The dorsal and ventral telencephalic regions are subdivided into four major domains.

Figure 2

The dorsal and ventral subdivisions of the embryonic mouse telencephalon at embryonic day (E) 9.0 (a), and the four broad subdivisions at E10.0 (b). In both schematics, dorsal is up, ventral is down. The Gli3-expressing dorsal region at E9.0 is split, by E10.0, into a bone morphogenetic protein (BMP)- and Wingless/Int protein (WNT)-expressing medial region and a more lateral cortical region that expresses countergradients of empty spiracles homeobox 2 (Emx2) and paired box 6 (Pax6). The ventral region at E9.0 is split, by E10.0, into medial Nkx2.1-expressing domains and lateral Gsh2-expressing domains. At E10.0 the expression domain of Gsh2 overlaps with that of Nkx2.1; this is not represented for the sake of illustrative simplicity. Similarly, sonic hedgehog (Shh), fibroblast growth factor (FGF) and forkhead box G1 (Foxg1) expression at E10.0 is omitted.