Fig. 5.
Excess iron attenuates the lethality of P. aeruginosa PAO1 in animal models. (A) Depletion of iron in intestinal mucus of mice subjected to 30% hepatectomy. n = 5 per group in 2 independent experiments, P < 0.05. (B) Supplementation of P. aeruginosa with 250 μM Fe2(SO4)3 significantly attenuates mortality in mice. n = 10/group in 2 independent experiments. (C) Supplementation of P. aeruginosa with 150 or 300 μM Fe3+significantly attenuates mortality in prefasted C. elegans feeding on NGM↓Pi P. aeruginosa lawns. n = 40/group in 2 independent experiments.