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Models for translesion DNA polymerase function during replication in the presence of DNA damage. (A) Translesional polymerases (green circles) replace Pol III (red circles) at replication forks (i), slowing the speed of replication and allowing more time for the damage (blue Xs) to be repaired (ii). (B) After replication encounters unrepaired damage (i), the translesion DNA polymerases function to fill in the gaps left in the DNA at these sites (ii).
