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. 2009 Jan 29;85(5):788–795. doi: 10.1189/jlb.1008671

Fig. 4.

Fig. 4.

Mechanisms underlying the down-regulation of genes 24 h after CpG ODN administration. All genes up-regulated 3 h after CpG treatment are shown (modified from Fig. 2). Genes that remain active through 24 h are highlighted in pink (P<0.00001), and those whose expression fell to background are in green. (A) Green arrows identify genes down-regulated by suppressors. Note that 33/35 of the genes targeted by suppressors (circled in green) are down-regulated and that five suppressors (SOCS1, SOCS3, IL1RN, NFKBIA, and IL10) target the major inducer TNF. (B) As TNF levels decline, the level of expression of most genes regulated by TNF (yellow arrows) also falls (green circles). (C) IFNG up-regulates 92% of all genes that remain active at 24 h (red arrows leading to red circles). Of note, 84% of the genes regulated by IFNG but targeted by a suppressor declined to background levels by 24 h (red arrows leading to green circles).