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. 2009 May;23(5):1596–1606. doi: 10.1096/fj.08-121624

Figure 4.

Figure 4.

Silencing of PPARα or PPARγ potentiates HIV-1-induced MMP activity. PPARα or PPARγ was silenced in normal hCMEC/D3 cells as described in Materials and Methods. Silencing procedure resulted in a 70–80% depletion of individual PPAR proteins (A). hCMEC/D3 cells transfected with control or PPARα- or PPARγ-specific siRNA were exposed to HIV-1-infected or control monocytes for 24 h, followed by determination of MMP-2 (B) and MMP-9 (C) activities by zymography. Results are means ± se of 4 separate experiments. *P < 0.05 vs. respective control. †P < 0.05 vs. control siRNA treatment. #P < 0.05 vs. baseline values.