Figure 2.

Radiotelemetry-based blood pressure recordings in vivo. a) Representative raw arterial pressure and heart rate trace recording baseline circadian rhythms from Ntg and Tg mice over the course of 5 days. b) Mean systolic arterial pressure (left), diastolic arterial pressure (middle), and heart rate (right) during a given 24 h of baseline analysis for Ntg (▪) and Tg (□) mice. c) Representative raw pressure traces during 40 min of exposure to 40% CO₂ for Ntg and Tg mice. d) Average change in systolic arterial blood pressure at baseline (▪) and at the onset of acidosis (□), illustrating the stress response in both Ntg and Tg mice. e) Mean data for systolic and diastolic arterial pressure measurements between nontransgenic (•) and transgenic (○) mice during the time course of hypercapnic acidosis. f) Change in mean arterial pressure (MAP) from baseline to the completion of the hypercapnic acidosis challenge for Ntg (▪) and Tg (□) mice. Values are expressed as means ± se. Two-way repeated-measures ANOVA main effects: ‡P < 0.05 for time; †P < 0.05 for genotype. Two-way repeated measures ANOVA interaction effects: §P < 0.05 for time vs. genotype; *P < 0.05 for Ntg vs. Tg. Ntg, n = 4; Tg, n = 7.