Figure 4.

Summary of real-time in vivo hemodynamic data. a) Summarized mean data showing changes in cardiac functional and geometric parameters, including systolic pressure, end- diastolic pressure, +dP/dt, contractility index, ejection fraction, maximum volume, Tau, heart rate, and stroke work between Ntg (•) and Tg (○) mice during the time course of esmolol infusion and acute hypercapnic acidosis. b) Representative raw data (derived from 5-s averages) of end-systolic pressure, ejection fraction, maximum volume, and Tau during 20 min of esmolol plus acidosis, showing transgene enhancement (light gray) of cTnI A164H. Values are expressed as means ± se. Ntg, n = 6; Tg, n = 7.