TABLE 1.

Changes in cardiac function during acidosis

Parameter	Baseline	Nadir	End	Nadir to end
Echocardiography
Tg
EF (%)	62.2 ± 4.4	47.4 ± 7.6#	67.8 ± 4.5†	20.4 ± 4.8*
Vol s (μl)	19.7 ± 3.3	24.4 ± 4.9#	14.4 ± 3.4†	−10.1 ± 2.9*
TEI index	0.4 ± 0.03	0.6 ± 0.04#	0.5 ± 0.03†‡	−0.1 ± 0.0*
MV E (mm/s)	883.8 ± 24.4	541.1 ± 63.0#	803.6 ± 36.6†	262.5 ± 81.7*
Ntg
EF (%)	55.0 ± 4.1	23.6 ± 4.9#	23.6 ± 4.9‡	0.0 ± 0.0
Vol s (μl)	27.0 ± 2.6	45.8 ± 2.4#	40.6 ± 5.1‡	−5.1 ± 5.9
TEI index	0.40 ± 0.02	0.65 ± 0.03#	0.62 ± 0.05‡	−0.03 ± 0.07
MV E (mm/s)	1069.7 ± 57.1	646.6 ± 146.7#	646.6 ± 146.7‡	0.0 ± 0.0
Hemodynamics
Tg
CI (+dP/dt/mmHg)	196.9 ± 9.6	113.1 ± 2.4#	126.4 ± 6.7‡	12.2 ± 6.5*
Max vol (μl)	27.3 ± 4.1	36.3 ± 5.0#	32.5 ± 5.0‡	−3.8 ± 1.2*
EDp (mmHg)	6.2 ± 1.1	12.3 ± 1.8#	7.9 ± 1.8†	−4.4 ± 0.8*
Ea (ESp/SV)	5.4 ± 0.6	8.4 ± 0.4#	6.2 ± 0.7†	−2.2 ± 0.6*
Ntg
CI (+dP/dt/mmHg)	169.0 ± 26.6	95.7 ± 5.7#	0.0 ± 0.0	—
Max vol (μl)	28.1 ± 5.4	55.1 ± 5.5#	0.0 ± 0.0	—
EDp (mmHg)	4.0 ± 1.0	10.8 ± 1.7#	0.0 ± 0.0	—
Ea (ESp/SV)	6.2 ± 0.4	14.2 ± 2.5#	0.0 ± 0.0	—

Analysis of cardiac function during acidosis in Tg and Ntg mice showing changes between baseline, nadir (worst value for a given parameter), and end of challenge. All values are expressed as means ± se. Echocardiographic parameters: ejection fraction (EF), volume at systole (vol s), TEI index, and inflow velocity of mitral valve E wave (MV E). Tg, n = 7; Ntg, n = 5. Hemodynamic parameters: contractility index (CI), left ventricular maximum volume (max vol), end diastolic pressure (EDp), and arterial elastance (E_a). Tg, n = 7; Ntg, n = 6. 

^*P < 0.05 vs. a hypothetical zero; Dunnets one-sample t test with Wilcoxon signed-rank post hoc. 

^#P < 0.05 vs. baseline, 

^†P < 0.05 vs. nadir, 

^‡P < 0.05 vs. baseline; repeated-measures one-way ANOVA.