TABLE 1.
Changes in cardiac function during acidosis
| Parameter | Baseline | Nadir | End | Nadir to end |
|---|---|---|---|---|
| Echocardiography
| ||||
| Tg | ||||
| EF (%) | 62.2 ± 4.4 | 47.4 ± 7.6# | 67.8 ± 4.5† | 20.4 ± 4.8* |
| Vol s (μl) | 19.7 ± 3.3 | 24.4 ± 4.9# | 14.4 ± 3.4† | −10.1 ± 2.9* |
| TEI index | 0.4 ± 0.03 | 0.6 ± 0.04# | 0.5 ± 0.03†‡ | −0.1 ± 0.0* |
| MV E (mm/s) | 883.8 ± 24.4 | 541.1 ± 63.0# | 803.6 ± 36.6† | 262.5 ± 81.7* |
| Ntg | ||||
| EF (%) | 55.0 ± 4.1 | 23.6 ± 4.9# | 23.6 ± 4.9‡ | 0.0 ± 0.0 |
| Vol s (μl) | 27.0 ± 2.6 | 45.8 ± 2.4# | 40.6 ± 5.1‡ | −5.1 ± 5.9 |
| TEI index | 0.40 ± 0.02 | 0.65 ± 0.03# | 0.62 ± 0.05‡ | −0.03 ± 0.07 |
| MV E (mm/s) | 1069.7 ± 57.1 | 646.6 ± 146.7# | 646.6 ± 146.7‡ | 0.0 ± 0.0 |
| Hemodynamics
| ||||
| Tg | ||||
| CI (+dP/dt/mmHg) | 196.9 ± 9.6 | 113.1 ± 2.4# | 126.4 ± 6.7‡ | 12.2 ± 6.5* |
| Max vol (μl) | 27.3 ± 4.1 | 36.3 ± 5.0# | 32.5 ± 5.0‡ | −3.8 ± 1.2* |
| EDp (mmHg) | 6.2 ± 1.1 | 12.3 ± 1.8# | 7.9 ± 1.8† | −4.4 ± 0.8* |
| Ea (ESp/SV) | 5.4 ± 0.6 | 8.4 ± 0.4# | 6.2 ± 0.7† | −2.2 ± 0.6* |
| Ntg | ||||
| CI (+dP/dt/mmHg) | 169.0 ± 26.6 | 95.7 ± 5.7# | 0.0 ± 0.0 | — |
| Max vol (μl) | 28.1 ± 5.4 | 55.1 ± 5.5# | 0.0 ± 0.0 | — |
| EDp (mmHg) | 4.0 ± 1.0 | 10.8 ± 1.7# | 0.0 ± 0.0 | — |
| Ea (ESp/SV) | 6.2 ± 0.4 | 14.2 ± 2.5# | 0.0 ± 0.0 | — |
Analysis of cardiac function during acidosis in Tg and Ntg mice showing changes between baseline, nadir (worst value for a given parameter), and end of challenge. All values are expressed as means ± se. Echocardiographic parameters: ejection fraction (EF), volume at systole (vol s), TEI index, and inflow velocity of mitral valve E wave (MV E). Tg, n = 7; Ntg, n = 5. Hemodynamic parameters: contractility index (CI), left ventricular maximum volume (max vol), end diastolic pressure (EDp), and arterial elastance (Ea). Tg, n = 7; Ntg, n = 6.
P < 0.05 vs. a hypothetical zero; Dunnets one-sample t test with Wilcoxon signed-rank post hoc.
P < 0.05 vs. baseline,
P < 0.05 vs. nadir,
P < 0.05 vs. baseline; repeated-measures one-way ANOVA.