Figure 7.

Network analyses of brain tumor exosome proteins identified by proteomics and Western blot analysis. Eight networks were discerned using Ingenuity software (Table 2), with the two significant-scoring ones shown here. Proteins derived empirically from this study are shown as gray-filled symbols; direct protein-protein interactions are shown as solid lines; indirect interactions are shown as broken lines. A) Network 1 had pathways in “hematological, immunological, and respiratory disease.” B) Network 2 pathways were involved in “cell-cell signaling/interaction, cancer, and hematological system development and function.”