TABLE 2.

Ingenuity software pathway analyses, highest scoring networks

Network	Molecules in network	Score	Focus molecules	Top functions
1	ACTB, Akt, ALB, APOA1, CALR, Caspase, CCT2 CCT6A, CD9, ENO1, FTH1, GAPDH, GSTP1, Histone h3, Hsp70, Hsp90, HSP90AA1, HSPA8, HSPB1, Insulin, Jnk, Mapk, NFkB, P38, MAPK, PCNA, PDCD6IP, PGK1, PI3K, Pkc(s), PSMA2 RAN, RNA polymerase II, TF, TGFB1, VCP	55	22	Hematological disease, immunological disease, respiratory disease
2	ALDH7A1, C11ORF82, CD40, COL1A1, DPYSL2, EEF1B2, EIF3I, FCGR1B, GBP2, GPNMB, H2-Q10, IFNG, IGF1, IL1/IL6/TNF, IL1B, INCA, INSRR, LY6, NSMAF, P4HB PHGDH, PMK2, RNASE7, RPSA, SAA4, SCLY, SCUBE1, SLC11A, SP1, SP110, ST18, TPT1, TRAFD1, TUBB	17	9	Cell-to-cell signaling and interaction, cancer, hematological system development, and function

Proteins derived from brain tumor exosomes [by proteomics, Western blotting, and from our previous publication (14)] are underscored.