Table 3. Associations of the TNMD haplotypes with total AMD (exudative and atrophic) and exudative AMD in women.
|
Markers |
Frequency |
Total AMD | Exudative AMD | ||||
|---|---|---|---|---|---|---|---|
|
OR (95% CI) |
p |
OR (95% CI) |
p |
||||
| Haploblock 1 | |||||||
|
rs11798018 |
rs5966709 |
||||||
| A |
G |
0.437 |
|||||
| C |
T |
0.329 |
0.821 (0.541- 1.244) |
0.35 |
0.918 (0.618–1.365) |
0.674 |
|
| C |
G |
0.23 |
0.921 (0.627–1.353) |
0.681 |
0.853 (0.557–1.306) |
0.465 |
|
| Haploblock 2 | |||||||
|
rs2073163 |
rs1155974 |
||||||
| T |
C |
0.637 |
|||||
| C |
T |
0.287 |
1.411 (0.972–2.047) |
0.319 |
1.431 (0.979–2.091) |
0.064 |
|
| Markers associated with AMD in women | |||||||
|
rs7890586 |
rs2073163 |
rs1155974 |
|||||
| G |
T |
C |
0.513 |
||||
| G |
C |
T |
0.288 |
1.318 (0.875–1.986) |
0.187 |
1.330 (0.877–2.017) |
0.18 |
| A | T | C | 0.084 | 0.487 (0.241–0.986) | 0.046 | 0.475 (0.226–0.999) | 0.05 |
Haploblocks 1 and 2 are defined on the basis of solid spine of LD. In addition, a 3-marker haplotype was constructed of those markers that were associated with AMD in women. The haplotype analyses did not reveal a haplotype that would explain the results substantially better than the single-marker analyses. Abbreviations: odds ratio (OR); confidence interval (CI).