Figure 2.

The cDNA and amino acid sequences of human RNase9. The open reading frame contains 618 bp and encodes a 205-amino acid protein. The initial and terminal codons are boxed. The protein contains a putative signal peptide with a cleavage site between L₂₃ (star) and V₂₄. Predicted N-glycosylation sites (at N₁₃₁ and N₁₄₃; underscored), casein kinase II phosphorylation sites, (T₃₁DFD and T₁₈₁IND; circled), N-myristoylation sites (G₇₄MPLNH, G₁₂₆IRKCN, and G₁₃₅LVEGV; solid triangles), and a tyrosine kinase phosphorylation site (KGLVEGVY₁₄₁, open triangles) are shown. The location of the putative Big-1 domain (L₂₃VQFQ; star) and the pancreatic ribonuclease (shaded) also are shown.