Table 1. Statistical Classification Strategy using NMR spectra of CSF samples.
(A) SCS analysis with and without blood contaminated CSF samples. | |||
N | correct [%] | crisp [%] | |
1. Training set (all incl.) | |||
Control | 52 | 97 | 73 |
C.neoformans | 25 | 91 | 88 |
S.pneumoniae | 24 | 95 | 88 |
1. Validation set (all incl.) | |||
Control | 6 | 50 | 67 |
C.neoformans | 15 | 64 | 93 |
S.pneumoniae | 15 | 100 | 87 |
Final Training set (excl. blood contaminations) | |||
Control | 49 | 96 | 94 |
C.neoformans | 34 | 100 | 94 |
S.pneumoniae | 39 | 97 | 92 |
Final Validation set (excl. blood contaminations) | |||
Control | 12 | 100 | 92 |
C.neoformans | 6 | 100 | 100 |
S.pneumoniae | 6 | 100 | 84 |
Inclusion of an additional clinical isolate | |||
C.neoformans (WM1128) | 5 | 80 | 100 |
S.pneumoniae (99-235-2193) | 5 | 100 | 80 |